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Publication : The Calcium Channel Subunit Alpha2delta2 Suppresses Axon Regeneration in the Adult CNS.

First Author  Tedeschi A Year  2016
Journal  Neuron Volume  92
Issue  2 Pages  419-434
PubMed ID  27720483 Mgi Jnum  J:311068
Mgi Id  MGI:6765090 Doi  10.1016/j.neuron.2016.09.026
Citation  Tedeschi A, et al. (2016) The Calcium Channel Subunit Alpha2delta2 Suppresses Axon Regeneration in the Adult CNS. Neuron 92(2):419-434
abstractText  Injuries to the adult CNS often result in permanent disabilities because neurons lose the ability to regenerate their axon during development. Here, whole transcriptome sequencing and bioinformatics analysis followed by gain- and loss-of-function experiments identified Cacna2d2, the gene encoding the Alpha2delta2 subunit of voltage-gated calcium channels (VGCCs), as a developmental switch that limits axon growth and regeneration. Cacna2d2 gene deletion or silencing promoted axon growth in vitro. In vivo, Alpha2delta2 pharmacological blockade through Pregabalin (PGB) administration enhanced axon regeneration in adult mice after spinal cord injury (SCI). As PGB is already an established treatment for a wide range of neurological disorders, our findings suggest that targeting Alpha2delta2 may be a novel treatment strategy to promote structural plasticity and regeneration following CNS trauma.
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