| Primary Identifier | MGI:2150059 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Aqp5 |
| Transmission | Germline | Strain of Origin | C57BL/6J x (Rb(11.16)2H x Rb(16.17)32Lub)F1 |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A 1.8kb neomycin resistance cassette replaced parts of exon 2 and 4, all of exon 3, and all of introns 2 and 3. Northern blots of submandibular gland homogenates from homozygous mutant mice showed no detectable full-length Aqp5 transcripts. Immunocytochemistry of the salivary glands from homozygous mutant mice showed no detectable Aqp5 protein. |
