| First Author | Nürnberg A | Year | 2008 |
| Journal | J Biol Chem | Volume | 283 |
| Issue | 51 | Pages | 35526-31 |
| PubMed ID | 18854320 | Mgi Jnum | J:144584 |
| Mgi Id | MGI:3831243 | Doi | 10.1074/jbc.M804972200 |
| Citation | Nurnberg A, et al. (2008) Antagonistic regulation of neurite morphology through Gq/G11 and G12/G13. J Biol Chem 283(51):35526-31 |
| abstractText | The induction of neurite retraction and growth cone collapse via G-protein-coupled receptors is involved in developmental as well as regenerative processes. The role of individual G-protein-mediated signaling processes in the regulation of neurite morphology is still incompletely understood. Using primary neurons from brains lacking Galpha(q)/Galpha(11) or Galpha(12)/Galpha(13), we show here that G(12)/G(13)-mediated signaling is absolutely required for neurite retraction and growth cone collapse induced by the blood-borne factors lysophosphatidic acid and thrombin. Interestingly, the effects of lysophosphatidic acid were mediated mainly by G(13), whereas thrombin effects required G(12). Surprisingly, lack of Galpha(q)/Galpha(11) resulted in overshooting responses to both stimuli, indicating that G(q)/G(11)-mediated signaling most likely via activation of Rac antagonizes the effects of G(12)/G(13). |
