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Publication : Axial skeleton homeosis and forelimb malformations in Hoxd-11 mutant mice.

First Author  Favier B Year  1995
Journal  Proc Natl Acad Sci U S A Volume  92
Issue  1 Pages  310-4
PubMed ID  7816839 Mgi Jnum  J:22289
Mgi Id  MGI:70170 Doi  10.1073/pnas.92.1.310
Citation  Favier B, et al. (1995) Axial skeleton homeosis and forelimb malformations in Hoxd-11 mutant mice. Proc Natl Acad Sci U S A 92(1):310-4
abstractText  The Hoxd-11 gene was disrupted by homologous recombination in embryonic stem cells. We found that Hoxd-11-/- mutant mice are viable and display homeotic transformations of their sacral vertebrae, while their forelimbs present abnormalities of some metacarpals and of the first row of carpal bones. These results are discussed in the light of current models of tetrapod axial skeleton and limb patterning.
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