| First Author | Nalvarte I | Year | 2016 |
| Journal | Reproduction | Volume | 151 |
| Issue | 3 | Pages | 253-9 |
| PubMed ID | 26700939 | Mgi Jnum | J:231635 |
| Mgi Id | MGI:5771968 | Doi | 10.1530/REP-15-0522 |
| Citation | Nalvarte I, et al. (2016) Estrogen receptor beta controls MMP-19 expression in mouse ovaries during ovulation. Reproduction 151(3):253-9 |
| abstractText | Estrogen receptor beta (ERbeta/ESR2) has a central role in mouse ovaries, as ERbeta knockout (BERKO) mice are subfertile due to an increase in fibrosis around the maturing follicle and a decrease in blood supply. This has a consequence that these follicles rarely rupture to release the mature oocyte. Matrix metalloproteinases (MMPs) are modulators of the extracellular matrix, and the expression of one specific MMP, MMP-19, is normally increased in granulosa cells during their maturation until ovulation. In this study, we demonstrate that MMP-19 levels are downregulated in BERKO mouse ovaries. Using human MCF-7 cells that overexpress ERbeta, we could identify MMP-19 to be a transcriptional target of ligand-bound activated ERbeta acting on a specificity protein-1 binding site. These data provide a molecular explanation for the observed follicle rupture defect that contributes to the subfertility of female BERKO mice. |
