| First Author | Day M | Year | 2005 |
| Journal | Behav Brain Res | Volume | 164 |
| Issue | 1 | Pages | 128-31 |
| PubMed ID | 16054246 | Mgi Jnum | J:115451 |
| Mgi Id | MGI:3691730 | Doi | 10.1016/j.bbr.2005.05.011 |
| Citation | Day M, et al. (2005) Beta estrogen receptor knockout (BERKO) mice present attenuated hippocampal CA1 long-term potentiation and related memory deficits in contextual fear conditioning. Behav Brain Res 164(1):128-31 |
| abstractText | Estrogen has marked effects on hippocampal synaptic plasticity. We demonstrate that male and female 3-month-old beta estrogen receptor knockout (BERKO) mice show profound memory impairment in a hippocampus-mediated fear-conditioning paradigm. Subsequently, hippocampal slices prepared from behaviorally naive female BERKO mice were examined electrophysiologically. These were found to have robust synaptic deficits, compared to slices from age-matched wild type controls, both in terms of their input-output curves and their expression of long-term-potentiation in area CA1. This report provides the first concrete evidence of significant hippocampal synaptic plasticity and memory deficits in the BERKO mouse. |
