| First Author | Burns KA | Year | 2012 |
| Journal | Endocrinology | Volume | 153 |
| Issue | 8 | Pages | 3960-71 |
| PubMed ID | 22700766 | Mgi Jnum | J:189085 |
| Mgi Id | MGI:5444330 | Doi | 10.1210/en.2012-1294 |
| Citation | Burns KA, et al. (2012) Role of estrogen receptor signaling required for endometriosis-like lesion establishment in a mouse model. Endocrinology 153(8):3960-71 |
| abstractText | Endometriosis results from ectopic invasion of endometrial tissue within the peritoneal cavity. Aberrant levels of the estrogen receptor (ER), ERalpha and ERbeta, and higher incidence of autoimmune disorders are observed in women with endometriosis. An immunocompetent mouse model of endometriosis was used in which minced uterine tissue from a donor was dispersed into the peritoneal cavity of a recipient. Wild-type (WT), ERalpha-knockout (alphaERKO), and betaERKO mice were donors or recipients to investigate the roles of ERalpha, ERbeta, and estradiol-mediated signaling on endometriosis-like disease. Mice were treated with vehicle or estradiol, and resulting location, number, and size of endometriosis-like lesions were assessed. In comparison with WT lesions in WT hosts, alphaERKO lesions in WT hosts were smaller and fewer in number. The effect of ER status and estradiol treatment on nuclear receptor status, proliferation, organization, and inflammation within lesions were examined. alphaERKO lesions in WT hosts did not form distal to the incision site, respond to estradiol, or proliferate but did have increased inflammation. WT lesions in alphaERKO hosts did respond to estradiol, proliferate, and show decreased inflammation with treatment, but surprisingly, progesterone receptor expression and localization remained unchanged. Only minor differences were observed between WT lesions in betaERKO hosts and betaERKO lesions in WT hosts, demonstrating the estradiol-mediated signaling responses are predominately through ERalpha. In sum, these results suggest ER in both endometriosis-like lesions and their environment influence lesion characteristics, and understanding these interactions may play a critical role in elucidating this enigmatic disease. |
