| First Author | Juárez P | Year | 2013 |
| Journal | Behav Brain Res | Volume | 256 |
| Pages | 354-61 | PubMed ID | 23933143 |
| Mgi Jnum | J:202350 | Mgi Id | MGI:5518514 |
| Doi | 10.1016/j.bbr.2013.07.044 | Citation | Juarez P, et al. (2013) Serotonin2A/C receptors mediate the aggressive phenotype of TLX gene knockout mice. Behav Brain Res 256:354-61 |
| abstractText | Deleting the tailless (TLX) gene in mice produces a highly aggressive phenotype yet to be characterized in terms of heterozygous animals or neurotransmitter mechanisms. We sought to establish pharmacological control over aggression and study the role of serotonin (5-HT)2A/C receptors in mediating changes in aggression. We analyzed aggression in mice heterozygous (+/-) or homozygous (-/-) for the TLX gene and wild-types (+/+) using a resident-intruder paradigm. No +/+ mice were aggressive, 36% of +/- TLX and 100% of -/- TLX mice showed aggression. Dose-effect functions were established for clozapine (0.1-1.5mg/kg, ip), ketanserin (0.3-1.25mg/kg, ip), and (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane [(+/-)DOI] (0.5-2.0mg/kg, ip). Injecting clozapine decreased the frequency and duration of attacks for +/- TLX and -/- TLX mice. Clozapine did not decrease grooming in either +/- TLX or -/- TLX mice but may have increased locomotion for -/- TLX mice. Injecting ketanserin, a 5-HT2A/C receptor antagonist, produced differential decreases in frequency and latency to aggression between genotypes and corresponding increases in locomotor behavior. Injecting (+/-)DOI, a 5-HT2A/C receptor agonist, increased the frequency and duration of attacks, decreased the latency to attacks, and decreased locomotion in +/- and -/- TLX mice. Results of the current study suggest aggression displayed by TLX null and heterozygous mice involves 5-HT2A/C receptors. |
