| First Author | Licht AH | Year | 2006 |
| Journal | J Cell Biol | Volume | 175 |
| Issue | 6 | Pages | 981-91 |
| PubMed ID | 17158955 | Mgi Jnum | J:119115 |
| Mgi Id | MGI:3701187 | Doi | 10.1083/jcb.200605149 |
| Citation | Licht AH, et al. (2006) JunB is required for endothelial cell morphogenesis by regulating core-binding factor beta. J Cell Biol 175(6):981-91 |
| abstractText | The molecular mechanism triggering the organization of endothelial cells (ECs) in multicellular tubules is mechanistically still poorly understood. We demonstrate that cell-autonomous endothelial functions of the AP-1 subunit JunB are required for proper endothelial morphogenesis both in vivo in mouse embryos with endothelial-specific ablation of JunB and in in vitro angiogenesis models. By cDNA microarray analysis, we identified core-binding factor beta (CBFbeta), which together with the Runx proteins forms the heterodimeric core-binding transcription complex CBF, as a novel JunB target gene. In line with our findings, expression of the CBF target MMP-13 was impaired in JunB-deficient ECs. Reintroduction of CBFbeta into JunB-deficient ECs rescued the tube formation defect and MMP-13 expression, indicating an important role for CBFbeta in EC morphogenesis. |
