| First Author | Partanen J | Year | 1998 |
| Journal | Genes Dev | Volume | 12 |
| Issue | 15 | Pages | 2332-44 |
| PubMed ID | 9694798 | Mgi Jnum | J:49154 |
| Mgi Id | MGI:1276784 | Doi | 10.1101/gad.12.15.2332 |
| Citation | Partanen J, et al. (1998) Opposite phenotypes of hypomorphic and Y766 phosphorylation site mutations reveal a function for Fgfr1 in anteroposterior patterning of mouse embryos. Genes Dev 12(15):2332-44 |
| abstractText | Intercellular communication is needed for both the generation of the mesodermal germ layer and its division into distinct subpopulations. To dissect the functions of fibroblast growth factor receptor-1 (FGFR1) during mouse gastrulation as well as to gain insights into its possible roles during later embryonic development, we have introduced specific mutations into the Fg/r1 locus by gene targeting. Our results show functional dominance of one of the receptor isoforms and suggest a function for the autophosphorylation of site Y766 in the negative regulation of FGFR1 activity. Y766F and hypomorphic mutations in Fgfr1 generate opposite phenotypes in terms of homeotic vertebral transformations, suggesting a role for FGFR1 in patterning the embryonic anteriorposterior axis by way of regulation of Hox gene activity. |
