| Primary Identifier | MGI:2153353 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Fgfr1 |
| Transmission | Germline | Strain of Origin | 129S6/SvEvTac |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A neomycin resistance cassette replaced exon 3, which encodes the first Ig domain contained only in alpha isoforms of the protein. Western blot analysis demonstrated that the alpha isoforms of the protein were not expressed in E9.5 mutant embryos. RT-PCR analysis showed that an increased level of expression of "b" isoform transcripts may partially compensate for loss of alpha isoform expression, and the expression of the "c" isoform is apparently unaffected. |
