| First Author | Owen EH | Year | 1997 |
| Journal | Behav Neurosci | Volume | 111 |
| Issue | 2 | Pages | 292-300 |
| PubMed ID | 9106670 | Mgi Jnum | J:40226 |
| Mgi Id | MGI:87569 | Doi | 10.1037//0735-7044.111.2.292 |
| Citation | Owen EH, et al. (1997) Identification of quantitative trait loci involved in contextual and auditory-cued fear conditioning in BXD recombinant inbred strains. Behav Neurosci 111(2):292-300 |
| abstractText | Fear conditioning shows associations formed between contextual or auditory stimuli with an unconditioned stimulus. Inbred mouse strains differ in their ability to demonstrate fear conditioning, suggesting at least a partial genetic influence. The present study identified the possible chromosomal loci regulating fear conditioning in BXD recombinant inbred strains using quantitative trait loci (QTL) analysis. Estimates of heritability for all 3 measures of conditioning were about .28. Correlational analyses between genetic markers and strain means identified multiple putative QTLs. The strongest associations were on Chromosomes 1 and 17 for freezing to the context, Chromosome 12 for freezing to an altered context, and Chromosome 1 for freezing to the auditory stimulus. Overlapping QTLs may indicate some common genes that underlie aspects of this learning task. |
