| First Author | Higashi S | Year | 1998 |
| Journal | J Cancer Res Clin Oncol | Volume | 124 |
| Issue | 12 | Pages | 670-6 |
| PubMed ID | 9879827 | Mgi Jnum | J:51984 |
| Mgi Id | MGI:1327531 | Doi | 10.1007/s004320050230 |
| Citation | Higashi S, et al. (1998) Host genes affecting survival period of chemically induced bladder cancer in mice. J Cancer Res Clin Oncol 124(12):670-6 |
| abstractText | Treatment of C57BL/6 J (B6) and NON male mice with N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) resulted in a high incidence of bladder cancer. The mean survival period, however, differed significantly by strain: 481+/-219 days in B6 (n = 31) and 203+/-119 days in NON (n = 30) (P < 0.0001). Major causes of death were renal failure due to obstruction of the urinary tract, or local invasion of tumors. The fact that the BBN-treated NON x B6 reciprocal F1 mice had survival periods as short as those of the parental NON mice suggests a genetically dominant susceptibility in NON or recessive resistance in B6. A linkage analysis of 248 back-cross mice to B6 suggested at least two quantitative trait loci determining the length of the survival period: one was mapped close to D2Mit260 (logarithm of odds, LOD, score 2.21), a microsatellite marker locus 83 cM from the centromere on chromosome 2, and another was close to D6Mit159, 7 cM from the centromere on chromosome 6 (LOD score 2.51). |
