| First Author | van der Weyden L | Year | 2016 |
| Journal | J Pathol | Volume | 238 |
| Issue | 2 | Pages | 152-65 |
| PubMed ID | 26354726 | Mgi Jnum | J:227719 |
| Mgi Id | MGI:5702526 | Doi | 10.1002/path.4632 |
| Citation | van der Weyden L, et al. (2016) Cross-species models of human melanoma. J Pathol 238(2):152-65 |
| abstractText | Although transformation of melanocytes to melanoma is rare, the rapid growth, systemic spread, as well as the chemoresistance of melanoma present significant challenges for patient care. Here we review animal models of melanoma, including murine, canine, equine, and zebrafish models, and detail the immense contribution these models have made to our knowledge of human melanoma development, and to melanocyte biology. We also highlight the opportunities for cross-species comparative genomic studies of melanoma to identify the key molecular events that drive this complex disease. (c) 2015 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland. |
