| First Author | Lu LM | Year | 1999 |
| Journal | Cancer Res | Volume | 59 |
| Issue | 11 | Pages | 2593-5 |
| PubMed ID | 10363979 | Mgi Jnum | J:55364 |
| Mgi Id | MGI:1337860 | Citation | Lu LM, et al. (1999) Bone marrow pre-B-1 (Bomb1): a quantitative trait locus inducing bone marrow pre-B-cell expansion in lymphoma-prone SL/Kh mice. Cancer Res 59(11):2593-5 |
| abstractText | Abnormalities of regulatory genes in early B-cell development often lead to lymphomagenesis. Our previous study shelved that there is an abnormal transient expansion of bone marrow (BM) pre-B cells in lymphoma- prone SL/Kh strain mice. Such expansion is a genetic property of SL/Kh stem cells rather than BM microenvironments. Using the percentage of BP1(+)B220(+) pre-B cells in total BM lymphoid cells as a quantitative parameter, we studied the genetic control of BM pre-B cells in 159 F-2 offspring of crosses between SL/Kh and NFS/N mice and 334 back-crosses to SL/Kh mice. A highly significant quantitative trait locus was identified on the distal segment of chromosome 3, shelving logarithm of odds scores of 22,7 in the F-2 cohort and 10.7 in beck-cross mice. This quantitative trait locus, named bone marrow pre- B-1, colocalized with lymphoid enhancer factor-1, which encodes a high mobility group DNA-binding protein that is expressed in T and pre-B cells. |
