| First Author | Sundvall M | Year | 1995 |
| Journal | Nat Genet | Volume | 10 |
| Issue | 3 | Pages | 313-7 |
| PubMed ID | 7545492 | Mgi Jnum | J:26734 |
| Mgi Id | MGI:74166 | Doi | 10.1038/ng0795-313 |
| Citation | Sundvall M, et al. (1995) Identification of murine loci associated with susceptibility to chronic experimental autoimmune encephalomyelitis. Nat Genet 10(3):313-7 |
| abstractText | B10.RIII mice develop chronic and relapsing experimental autoimmune encephalomyelitis (EAE) after immunization with the myelin basic protein (MBP) peptide 89-101. The disease is associated with the major histocompatibility complex (MHC) (eae1). We have now investigated the importance of non-MHC regions for the EAE susceptibility in a cross between RIIIS/J and B10.RIII mice which share the MHC region but differ in disease susceptibility. Linkage analysis using microsatellite markers spanning the genome identified a region (eae2) on chromosome 15 which showed linkage to disease (P = 0.0002). Our data also suggest linkage to a second region (eae3) on chromosome 3 (P = 0.0024), and provide evidence for locus interactions between eae2 and eae3. These results provide clues to the genetic basis of multiple sclerosis. |
