| First Author | Shirley RL | Year | 2004 |
| Journal | Nat Neurosci | Volume | 7 |
| Issue | 7 | Pages | 699-700 |
| PubMed ID | 15208631 | Mgi Jnum | J:91275 |
| Mgi Id | MGI:3046374 | Doi | 10.1038/nn1271 |
| Citation | Shirley RL, et al. (2004) Mpdz is a quantitative trait gene for drug withdrawal seizures. Nat Neurosci 7(7):699-700 |
| abstractText | Physiological dependence and associated withdrawal episodes can constitute a powerful motivational force that perpetuates drug use and abuse. Using robust behavioral models of drug physiological dependence in mice, positional cloning, and sequence and expression analyses, we identified an addiction-relevant quantitative trait gene, Mpdz. Our findings provide a framework to define the protein interactions and neural circuit by which this gene's product (multiple PDZ domain protein) affects drug dependence, withdrawal and relapse. |
