| Primary Identifier | MGI:2155955 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Ace |
| Transmission | Germline | Strain of Origin | Not Specified |
| Is Recombinase | false | Is Wild Type | false |
| description | The Acetm1Mcf mouse may serve as useful model system to study the progression of the nephronophthisis-uremic medullary cystic disease complex, a group of disorders that cause renal failure and are characterized by medullary cysts, corticotubular atrophy, interstitial inflammation, water wasting and uremia. |
| molecularNote | The authors mutated the gene to eliminate expression from the somatic promoter of the gene while preserving expression from the testicular promoter. Specific construct details were not available. Homozygous mutant mice lack the protein in all tissues except the testes. |
