| First Author | Wöhner M | Year | 2016 |
| Journal | J Exp Med | Volume | 213 |
| Issue | 7 | Pages | 1201-21 |
| PubMed ID | 27261530 | Mgi Jnum | J:236268 |
| Mgi Id | MGI:5805606 | Doi | 10.1084/jem.20152002 |
| Citation | Wohner M, et al. (2016) Molecular functions of the transcription factors E2A and E2-2 in controlling germinal center B cell and plasma cell development. J Exp Med 213(7):1201-21 |
| abstractText | E2A is an essential regulator of early B cell development. Here, we have demonstrated that E2A together with E2-2 controlled germinal center (GC) B cell and plasma cell development. As shown by the identification of regulated E2A,E2-2 target genes in activated B cells, these E-proteins directly activated genes with important functions in GC B cells and plasma cells by inducing and maintaining DNase I hypersensitive sites. Through binding to multiple enhancers in the Igh 3' regulatory region and Aicda locus, E-proteins regulated class switch recombination by inducing both Igh germline transcription and AID expression. By regulating 3' Igk and Igh enhancers and a distal element at the Prdm1 (Blimp1) locus, E-proteins contributed to Igk, Igh, and Prdm1 activation in plasmablasts. Together, these data identified E2A and E2-2 as central regulators of B cell immunity. |
