| First Author | Nakayama K | Year | 1993 |
| Journal | Science | Volume | 261 |
| Issue | 5128 | Pages | 1584-8 |
| PubMed ID | 8372353 | Mgi Jnum | J:14685 |
| Mgi Id | MGI:62849 | Doi | 10.1126/science.8372353 |
| Citation | Nakayama K, et al. (1993) Disappearance of the lymphoid system in Bcl-2 homozygous mutant chimeric mice. Science 261(5128):1584-8 |
| abstractText | The bcl-2 proto-oncogene can prevent the death of many cell types. Mice were generated that were chimeric for the homozygous inactivation of bcl-2. Lymphocytes without Bcl-2 differentiated into phenotypically mature cells. However, in vitro, the mature T cells that lacked Bcl-2 had shorter life-spans and increased sensitivity to glucocorticoids and gamma-irradiation. In contrast, stimulation of CD3 inhibited the death of these cells. T and B cells with no Bcl-2 disappeared from the bone marrow, thymus, and periphery by 4 weeks of age. Thus, Bcl-2 was dispensable for lymphocyte maturation, but was required for a stable immune system after birth. |
