| First Author | Matsuzaki Y | Year | 1997 |
| Journal | Blood | Volume | 89 |
| Issue | 3 | Pages | 853-62 |
| PubMed ID | 9028316 | Mgi Jnum | J:38087 |
| Mgi Id | MGI:85476 | Doi | 10.1182/blood.v89.3.853 |
| Citation | Matsuzaki Y, et al. (1997) Role of bcl-2 in the development of lymphoid cells from the hematopoietic stem cell. Blood 89(3):853-62 |
| abstractText | To investigate the role of bcl-2 in lymphohematopoiesis, a long-term bone marrow reconstitution system was established. Transplantation of 1,000 c-Kit+ Sca-1+ and lineage markers negative cells from bcl-2-l-mouse bone marrow resulted in long-term reconstitution of nonlymphoid cells. However, T cells were totally absent and B-lymphocyte development was severely impaired at a very early stage of differentiation in the chimeric mouse. On the other hand, transplantation of day 14 fetal liver cells from bcl-2-l-mice resulted in generation of both T and B cells in the recipient, albeit transiently. These data suggest that bcl-2 plays a critical role in the development of lymphoid progenitor cells from the hematopoietic stem cell (HSC), but is not essential for the development of nonlymphoid cells and the self-renewal of HSC. In addition, lymphopoiesis from fetal liver HSC appears to be less dependent on bcl-2 than adult bone marrow HSC. |
