| First Author | Huang ZL | Year | 2005 |
| Journal | Nat Neurosci | Volume | 8 |
| Issue | 7 | Pages | 858-9 |
| PubMed ID | 15965471 | Mgi Jnum | J:99612 |
| Mgi Id | MGI:3583073 | Doi | 10.1038/nn1491 |
| Citation | Huang ZL, et al. (2005) Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine. Nat Neurosci 8(7):858-9 |
| abstractText | Caffeine, a component of tea, coffee and cola, induces wakefulness. It binds to adenosine A1 and A2A receptors as an antagonist, but the receptor subtype mediating caffeine-induced wakefulness remains unclear. Here we report that caffeine at 5, 10 and 15 mg kg(-1) increased wakefulness in both wild-type mice and A1 receptor knockout mice, but not in A2A receptor knockout mice. Thus, caffeine-induced wakefulness depends on adenosine A2A receptors. |
