| First Author | Chandran V | Year | 2016 |
| Journal | Neuron | Volume | 89 |
| Issue | 5 | Pages | 956-70 |
| PubMed ID | 26898779 | Mgi Jnum | J:253247 |
| Mgi Id | MGI:6109658 | Doi | 10.1016/j.neuron.2016.01.034 |
| Citation | Chandran V, et al. (2016) A Systems-Level Analysis of the Peripheral Nerve Intrinsic Axonal Growth Program. Neuron 89(5):956-70 |
| abstractText | The regenerative capacity of the injured CNS in adult mammals is severely limited, yet axons in the peripheral nervous system (PNS) regrow, albeit to a limited extent, after injury. We reasoned that coordinate regulation of gene expression in injured neurons involving multiple pathways was central to PNS regenerative capacity. To provide a framework for revealing pathways involved in PNS axon regrowth after injury, we applied a comprehensive systems biology approach, starting with gene expression profiling of dorsal root ganglia (DRGs) combined with multi-level bioinformatic analyses and experimental validation of network predictions. We used this rubric to identify a drug that accelerates DRG neurite outgrowth in vitro and optic nerve outgrowth in vivo by inducing elements of the identified network. The work provides a functional genomics foundation for understanding neural repair and proof of the power of such approaches in tackling complex problems in nervous system biology. |
