| First Author | Kohlhapp FJ | Year | 2016 |
| Journal | Cell Rep | Volume | 17 |
| Issue | 4 | Pages | 957-965 |
| PubMed ID | 27760326 | Mgi Jnum | J:240819 |
| Mgi Id | MGI:5896474 | Doi | 10.1016/j.celrep.2016.09.068 |
| Citation | Kohlhapp FJ, et al. (2016) Non-oncogenic Acute Viral Infections Disrupt Anti-cancer Responses and Lead to Accelerated Cancer-Specific Host Death. Cell Rep 17(4):957-965 |
| abstractText | In light of increased cancer prevalence and cancer-specific deaths in patients with infections, we investigated whether infections alter anti-tumor immune responses. We report that acute influenza infection of the lung promotes distal melanoma growth in the dermis and leads to accelerated cancer-specific host death. Furthermore, we show that during influenza infection, anti-melanoma CD8+ T cells are shunted from the tumor to the infection site, where they express high levels of the inhibitory receptor programmed cell death protein 1 (PD-1). Immunotherapy to block PD-1 reverses this loss of anti-tumor CD8+ T cells from the tumor and decreases infection-induced tumor growth. Our findings show that acute non-oncogenic infection can promote cancer growth, raising concerns regarding acute viral illness sequelae. They also suggest an unexpected role for PD-1 blockade in cancer immunotherapy and provide insight into the immune response when faced with concomitant challenges. |
