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Publication : Laminar and compartmental regulation of dendritic growth in mature cortex.

First Author  Chow DK Year  2009
Journal  Nat Neurosci Volume  12
Issue  2 Pages  116-8
PubMed ID  19151711 Mgi Jnum  J:145970
Mgi Id  MGI:3836378 Doi  10.1038/nn.2255
Citation  Chow DK, et al. (2009) Laminar and compartmental regulation of dendritic growth in mature cortex. Nat Neurosci 12(2):116-8
abstractText  Can dendrites grow in mature cortex? We used chronic in vivo imaging to follow pyramidal neurons before and after cortical deletion of the Pten tumor suppressor gene in mature mice. We found that Pten/mTOR signaling uniquely regulates the growth of layer 2/3 apical dendrites; no effects of gene deletion were observed on basal dendrites of these pyramidal neurons or along layer 5 apical dendrites.
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