| First Author | Huang Y | Year | 2011 |
| Journal | Cell Biol Int | Volume | 35 |
| Issue | 9 | Pages | 905-8 |
| PubMed ID | 21524277 | Mgi Jnum | J:329567 |
| Mgi Id | MGI:7346423 | Doi | 10.1042/CBI20110161 |
| Citation | Huang Y, et al. (2011) Dispensable role of PTEN in mouse spermatogenesis. Cell Biol Int 35(9):905-8 |
| abstractText | PTEN (phosphatase and tensin homologue deleted on chromosome ten) plays critical roles in multiple cellular processes, including cell proliferation, survival, migration and transformation. A role of PTEN in mammalian spermatogenesis, however, has not been explored. To address this question, we generated a mouse model with PTEN conditional knockout in postnatal male germ cells. We found that spermatogenesis was normal in PTEN-deleted male germ cells. PTEN conditional mutant males produced sperm and sired offspring as competently as wild-type littermates. Moreover, our biochemical analysis also indicated that the Akt (acutely transforming retrovirus AKT8 in rodent T cell lymphoma) signalling pathway was not affected in mutant testis. Taken together, these findings demonstrate that PTEN is dispensable in mouse spermatogenesis. |
