| First Author | Wong DM | Year | 2016 |
| Journal | Cell Rep | Volume | 14 |
| Issue | 6 | Pages | 1488-1499 |
| PubMed ID | 26832406 | Mgi Jnum | J:230105 |
| Mgi Id | MGI:5755428 | Doi | 10.1016/j.celrep.2016.01.012 |
| Citation | Wong DM, et al. (2016) The Transcription Factor ASCIZ and Its Target DYNLL1 Are Essential for the Development and Expansion of MYC-Driven B Cell Lymphoma. Cell Rep 14(6):1488-99 |
| abstractText | How MYC promotes the development of cancer remains to be fully understood. Here, we report that the Zn(2+)-finger transcription factor ASCIZ (ATMIN, ZNF822) synergizes with MYC to activate the expression of dynein light chain (DYNLL1, LC8) in the murine Emu-Myc model of lymphoma. Deletion of Asciz or Dynll1 prevented the abnormal expansion of pre-B cells in pre-cancerous Emu-Myc mice and potentiated the pro-apoptotic activity of MYC in pre-leukemic immature B cells. Constitutive loss of Asciz or Dynll1 delayed lymphoma development in Emu-Myc mice, and induced deletion of Asciz in established lymphomas extended the survival of tumor-bearing mice. We propose that ASCIZ-dependent upregulation of DYNLL1 levels is essential for the development and expansion of MYC-driven lymphomas by enabling the survival of pre-neoplastic and malignant cells. |
