| First Author | Kamoto T | Year | 1996 |
| Journal | Jpn J Cancer Res | Volume | 87 |
| Issue | 4 | Pages | 401-4 |
| PubMed ID | 8641972 | Mgi Jnum | J:33016 |
| Mgi Id | MGI:80504 | Doi | 10.1111/j.1349-7006.1996.tb00236.x |
| Citation | Kamoto T, et al. (1996) A quantitative trait locus in major histocompatibility complex determining latent period of mouse lymphomas. Jpn J Cancer Res 87(4):401-4 |
| abstractText | The effects of two host genes on retrovirus-induced murine lymphoma were evaluated by studying 114 F2 intercross mice between SL/Kh and AKR/Ms mice, Out of 47 T-lymphoma- bearing F2 mice, 45 had the AKR-derived dominant allele at Tlsm-1. The length of the lymphoma latent period was not related to type of tumor, Instead, it was significantly shortened by a recessive SL/Kh-derived allele at a major histocompatibility complex (MHC)-linked locus on Chr. 17. A quantitative trait analysis of the latent period yielded a maximal logarithm of likelihood ratio for linkage (LOD) score of 7.06 at a class II gene within MHC, The SL/Kh- derived recessive gene was named lla (lymphoma latency acceleration). |
