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Allele : Wrn<tm1Led> Werner syndrome RecQ like helicase; targeted mutation 1, Philip Leder

Primary Identifier	MGI:2156622	Allele Type	Targeted
Attribute String	Null/knockout	Gene	Wrn
Transmission	Germline	Strain of Origin	129S6/SvEvTac
Is Recombinase	false	Is Wild Type	false

molecularNote

Exons 3 and 4 were replaced with a neomycin selection cassette. The targeted allele is expected to express a fully translated protein that lacks 121 amino acids of the helicase domain.

mutations:
Insertion,
Intragenic deletion

cellLines:
Not Specified

synonyms:
WS,
Wrn<deltahel>,
WS,
Wrn<deltahel>

earliestPublication:
Lebel M, et al. (1998) A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity. Proc Natl Acad Sci U S A 95(22):13097-102

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

1 Carried By

0 Driven By

20 Publication categories

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