Primary Identifier | MGI:2156945 | Allele Type | Targeted |
Attribute String | Conditional ready, No functional change | Gene | Itgb1 |
Transmission | Germline | Strain of Origin | 129X1/SvJ |
Is Recombinase | false | Is Wild Type | false |
molecularNote | LoxP sites were inserted flanking the first coding exon as follows: One loxP site was inserted 5' to the exon and a loxP-flanked neomycin and thymidine kinase selection cassette was inserted 3' to the exon. The neomycin and thymidine kinase selection cassette was removed via Cre-mediated recombination in ES cells prior to creation of chimeric mice, leaving one loxP site in place of the cassette. |