| First Author | Okazaki H | Year | 2018 |
| Journal | Neurosci Lett | Volume | 671 |
| Pages | 99-102 | PubMed ID | 29427598 |
| Mgi Jnum | J:261647 | Mgi Id | MGI:6155972 |
| Doi | 10.1016/j.neulet.2018.02.006 | Citation | Okazaki H, et al. (2018) Calcineurin knockout mice show a selective loss of small spines. Neurosci Lett 671:99-102 |
| abstractText | Calcineurin is required for long-term depression and activity-dependent spine shrinkage, and calcineurin mutations have been identified in patients with schizophrenia. Moreover, mice with conditional knockout of calcineurin B (CNB-KO) exhibit behavioral abnormalities suggestive of schizophrenia. Changes in the dendritic spines of these mice, however, have not been investigated. We therefore examined the dendritic spines of CNB-KO mice, and observed a significant reduction in small spines and an increase in large spines in the prefrontal and visual cortices. The effect of CNB-KO on the spine sizes was relatively moderate, possibly due to the presence of spontaneous fluctuations (dynamics) in the dendritic spines themselves. Thus, CNB-KO mice showed a spine phenotype similar to those recently reported in patients with schizophrenia. |
