| First Author | Flamant F | Year | 2002 |
| Journal | Mol Endocrinol | Volume | 16 |
| Issue | 1 | Pages | 24-32 |
| PubMed ID | 11773436 | Mgi Jnum | J:73626 |
| Mgi Id | MGI:2156109 | Doi | 10.1210/mend.16.1.0766 |
| Citation | Flamant F, et al. (2002) Congenital Hypothyroid Pax8(-/-) Mutant Mice Can Be Rescued by Inactivating the TRalpha Gene. Mol Endocrinol 16(1):24-32 |
| abstractText | Mice devoid of all TRs are viable, whereas Pax8(-/-) mice, which lack the follicular cells producing T(4) and T(3) in the thyroid gland, die during the first weeks of postnatal life. A precise comparison between the two types of mutants reveals that their phenotypes are similar, but the defects in spleen, bone, and small intestine are more pronounced in Pax8(-/-) mice. This is interpreted as the result of a negative effect of the unliganded TR on thyroid hormone target genes expression in the Pax8(-/-) mutants. Pax8/TRalpha compound mutants can survive to adulthood, and the expression of target genes is partially restored. This demonstrates the importance of TRalpha aporeceptor activity in several aspects of postnatal development. |
