| First Author | Heeger PS | Year | 2005 |
| Journal | J Exp Med | Volume | 201 |
| Issue | 10 | Pages | 1523-30 |
| PubMed ID | 15883171 | Mgi Jnum | J:99214 |
| Mgi Id | MGI:3581484 | Doi | 10.1084/jem.20041967 |
| Citation | Heeger PS, et al. (2005) Decay-accelerating factor modulates induction of T cell immunity. J Exp Med 201(10):1523-30 |
| abstractText | Decay-accelerating factor (Daf) dissociates C3/C5 convertases that assemble on host cells and thereby prevents complement activation on their surfaces. We demonstrate that during primary T cell activation, the absence of Daf on antigen-presenting cells (APCs) and on T cells enhances T cell proliferation and augments the induced frequency of effector cells. The effect is factor D- and, at least in part, C5-dependent, indicating that local alternative pathway activation is essential. We show that cognate T cell-APC interactions are accompanied by rapid production of alternative pathway components and down-regulation of Daf expression. The findings argue that local alternative pathway activation and surface Daf protein function respectively as a costimulator and a negative modulator of T cell immunity and explain previously reported observations linking complement to T cell function. The results could have broad therapeutic implications for disorders in which T cell immunity is important. |
