| Primary Identifier | MGI:2157240 | Allele Type | Targeted |
| Attribute String | Humanized sequence, Inserted expressed sequence, Modified isoform(s), Null/knockout | Gene | Apoe |
| Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A DNA fragment containing exons 2-4 of the human APOE gene (the APOE3 isoform) replaced an equivalent portion of the mouse Apoe gene. Western blot analysis on plasma derived from homozygous mice demonstrated that the human protein was expressed from this allele and the endogenous mouse protein was not detectable. |
