| First Author | Helmby H | Year | 2004 |
| Journal | Eur J Immunol | Volume | 34 |
| Issue | 12 | Pages | 3674-81 |
| PubMed ID | 15549727 | Mgi Jnum | J:94568 |
| Mgi Id | MGI:3513498 | Doi | 10.1002/eji.200425452 |
| Citation | Helmby H, et al. (2004) Interleukin 1 plays a major role in the development of Th2-mediated immunity. Eur J Immunol 34(12):3674-81 |
| abstractText | Expulsion of the gastrointestinal nematode Trichuris muris is mediated by a T helper (Th)2-type response, involving interleukin (IL)-4, IL-9 and IL-13. Here, we show that Th2 response-associated resistance is dependent on the presence of IL-1alpha and IL-1beta. When lymph node cells from naive IL-1alpha- or IL-1beta-deficient mice were subjected to Th2 polarization in vitro, they failed to polarize in the presence of IL-4 alone, but required the addition of exogenous IL-1alpha or IL-1beta. Furthermore, we demonstrate that both IL-1alpha- and IL-1beta-deficient mice are susceptible to chronic T. muris infection and that the inability to expel the worms is associated with a defect in the development of a Th2 response in the mesenteric lymph nodes. These results provide the first demonstration of the critical role of IL-1 in regulating Th2 responses during gastrointestinal nematode infection. |
