| First Author | Pearce RB | Year | 1998 |
| Journal | Autoimmunity | Volume | 28 |
| Issue | 1 | Pages | 31-45 |
| PubMed ID | 9754812 | Mgi Jnum | J:49676 |
| Mgi Id | MGI:1277903 | Doi | 10.3109/08916939808993843 |
| Citation | Pearce RB (1998) Fine-mapping of the mouse T lymphocyte fraction (Tlf) locus on chromosome 9: association with autoimmune diabetes. Autoimmunity 28(1):31-45 |
| abstractText | Tlf (T lymphocyte fraction) defines a locus that governs the unusually high fraction of circulating T lymphocytes: in the nonobese diabetic (NOD) mouse, We previously mapped TIS to proximal Chromosome 9 in BCl mice.([1]) Here, Tlf was fine-mapped on Chromosome 9 using 8 markers covering the 43 cM interval from D9Mit90 at 9 cM to D9Mit35 at 52 cM. Markers for diabetic genes on Chromosomes 3, 4, 5, 6, and 17 were also examined for effects on the TIS phenotype. By both parametric and nonparametric tests, TIS associated with two areas on Chromosome 9, one with the segment bounded by D9Mit66 (15 cM) and D9Mit2 (17 cM) and a second region near D9Mit71 (29 cM), This linkage pattern was observed both in BCl and F2 populations, Thus, the Tlf phenotype is possibly governed by two genes on Chromosome 9. An influence by sex on the penetrance of TIS was evident in that linkage was strongest for female F2, mice and male BCl mice. One locus controlling the T lymphocyte fraction may be Idd2 since historically a subline of NOD mice with a low T cell fraction showed a low incidence of diabetes. Candidate es for Tlf are Ets1 and Fli1, proximally and Igif distally. |
