| First Author | Angel JM | Year | 1997 |
| Journal | Mol Carcinog | Volume | 20 |
| Issue | 2 | Pages | 162-7 |
| PubMed ID | 9364205 | Mgi Jnum | J:44548 |
| Mgi Id | MGI:1100432 | Doi | 10.1002/(sici)1098-2744(199710)20:2<162::aid-mc2>3.0.co;2-p |
| Citation | Angel JM, et al. (1997) Association of a murine chromosome 9 locus (Psl1) with susceptibility to mouse skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate. Mol Carcinog 20(2):162-7 |
| abstractText | It has been known for many years that there are dramatic differences in the susceptibility of mouse stocks and strains to two-stage skin carcinogenesis and that these differences are due to the animals' responsiveness to tumor-promoting agents. In earlier studies using several inbred mouse strains, we found that susceptibility to skin tumor promotion by phorbol esters such as 12-O- tetradecanoylphorbol-13-acetate (TPA) is a multigenic trait. To extend this work, we conducted a genome scan of (C57BL/6 x DBA/2)F-1 x C57BL/6 mice previously scored for sensitivity to skin tumor promotion by TPA. As a result of this scan, we now report an association of increased TPA promotion susceptibility with inheritance of the DBA/2 alleles of markers on the distal portion of mouse chromosome 9. Additional linkage analyses using (C57BL/6 x DBA/2)F-2 and BxD recombinant inbred mice confirmed this association and suggested that a TPA promotion susceptibility locus maps near D9Mit51 (LODw = 4.1). We designated this locus promotion susceptibility locus 1 (Ps/1). (C) 1997 Wiley-Liss, Inc. |
