| First Author | Seo SU | Year | 2015 |
| Journal | Immunity | Volume | 42 |
| Issue | 4 | Pages | 744-55 |
| PubMed ID | 25862092 | Mgi Jnum | J:229698 |
| Mgi Id | MGI:5753014 | Doi | 10.1016/j.immuni.2015.03.004 |
| Citation | Seo SU, et al. (2015) Distinct Commensals Induce Interleukin-1beta via NLRP3 Inflammasome in Inflammatory Monocytes to Promote Intestinal Inflammation in Response to Injury. Immunity 42(4):744-55 |
| abstractText | The microbiota stimulates inflammation, but the signaling pathways and the members of the microbiota involved remain poorly understood. We found that the microbiota induces interleukin-1beta (IL-1beta) release upon intestinal injury and that this is mediated via the NLRP3 inflammasome. Enterobacteriaceae and in particular the pathobiont Proteus mirabilis, induced robust IL-1beta release that was comparable to that induced by the pathogen Salmonella. Upon epithelial injury, production of IL-1beta in the intestine was largely mediated by intestinal Ly6C(high) monocytes, required chemokine receptor CCR2 and was abolished by deletion of IL-1beta in CCR2(+) blood monocytes. Furthermore, colonization with P. mirabilis promoted intestinal inflammation upon intestinal injury via the production of hemolysin, which required NLRP3 and IL-1 receptor signaling in vivo. Thus, upon intestinal injury, selective members of the microbiota stimulate newly recruited monocytes to induce NLRP3-dependent IL-1beta release, which promotes inflammation in the intestine. |
