| First Author | Barreiro O | Year | 2016 |
| Journal | Elife | Volume | 5 |
| PubMed ID | 27304075 | Mgi Jnum | J:269730 |
| Mgi Id | MGI:6207777 | Doi | 10.7554/eLife.15251 |
| Citation | Barreiro O, et al. (2016) Pivotal role for skin transendothelial radio-resistant anti-inflammatory macrophages in tissue repair. Elife 5:e15251 |
| abstractText | Heterogeneity and functional specialization among skin-resident macrophages are incompletely understood. In this study, we describe a novel subset of murine dermal perivascular macrophages that extend protrusions across the endothelial junctions in steady-state and capture blood-borne macromolecules. Unlike other skin-resident macrophages that are reconstituted by bone marrow-derived progenitors after a genotoxic insult, these cells are replenished by an extramedullary radio-resistant and UV-sensitive Bmi1(+) progenitor. Furthermore, they possess a distinctive anti-inflammatory transcriptional profile, which cannot be polarized under inflammatory conditions, and are involved in repair and remodeling functions for which other skin-resident macrophages appear dispensable. Based on all their properties, we define these macrophages as Skin Transendothelial Radio-resistant Anti-inflammatory Macrophages (STREAM) and postulate that their preservation is important for skin homeostasis. |
