| First Author | Daley-Bauer LP | Year | 2012 |
| Journal | Immunity | Volume | 37 |
| Issue | 1 | Pages | 122-33 |
| PubMed ID | 22840843 | Mgi Jnum | J:187387 |
| Mgi Id | MGI:5436346 | Doi | 10.1016/j.immuni.2012.04.014 |
| Citation | Daley-Bauer LP, et al. (2012) Cytomegalovirus impairs antiviral CD8+ T cell immunity by recruiting inflammatory monocytes. Immunity 37(1):122-33 |
| abstractText | Inflammatory monocytes are key early responders to infection that contribute to pathogen-host interactions in diverse ways. Here, we report that the murine cytomegalovirus-encoded CC chemokine, MCK2, enhanced CCR2-dependent recruitment of these cells to modulate antiviral immunity, impairing virus-specific CD8(+) T cell expansion and differentiation into effector cytotoxic T lymphocytes, thus reducing the capacity to eliminate viral antigen-bearing cells and slowing viral clearance. Adoptive transfer of inflammatory monocytes into Ccr2(-/-)Ccl2(-/-) mice impaired virus antigen-specific clearance. Cytomegalovirus therefore enhances a natural CCR2-dependent immune regulatory network to modulate adaptive immunity via nitric oxide production, reminiscent of the monocytic subtype of myeloid-derived suppressor cells primarily implicated in cancer immunomodulation. |
