| First Author | Liang XH | Year | 1999 |
| Journal | J Virol | Volume | 73 |
| Issue | 3 | Pages | 2563-7 |
| PubMed ID | 9971844 | Mgi Jnum | J:52841 |
| Mgi Id | MGI:1330500 | Doi | 10.1128/jvi.73.3.2563-2567.1999 |
| Citation | Liang XH, et al. (1999) Resistance of interleukin-1beta-deficient mice to fatal Sindbis virus encephalitis. J Virol 73(3):2563-7 |
| abstractText | Interleukin-1beta (IL-1beta) concentrations are frequently elevated in central nervous system (CNS) viral infections, but the pathophysiologic significance of such elevations is not known. To examine the role of IL-1beta in CNS viral pathogenesis, we compared the natural histories of IL-1beta-deficient and wild-type 129 SV(ev) mice infected with a neurovirulent viral strain, neuroadapted Sindbis virus (NSV). We found that the incidence of severe paralysis and death was markedly decreased in NSV-infected IL-1beta-/- mice compared to NSV-infected wild-type mice (4 versus 88%, P < 0.001). Despite this marked difference in clinical outcome, no differences in numbers of apoptotic cells or presence of histopathologic lesions in the brains of moribund wild-type mice and those of clinically healthy IL-1beta-/- mice could be detected. These results suggest that IL-1beta deficiency is protective against fatal Sindbis virus infection by a mechanism that does not involve resistance to CNS virus-induced apoptosis or histopathology. |
