| First Author | Edwards HM | Year | 2023 |
| Journal | Brain | Volume | 146 |
| Issue | 6 | Pages | 2268-2274 |
| PubMed ID | 37127299 | Mgi Jnum | J:349780 |
| Mgi Id | MGI:7658013 | Doi | 10.1093/brain/awad052 |
| Citation | Edwards HM, et al. (2023) Sex-dependent effects of acute stress on amyloid-beta in male and female mice. Brain 146(6):2268-2274 |
| abstractText | The risk of developing Alzheimer's disease is mediated by a combination of genetics and environmental factors, such as stress, sleep abnormalities and traumatic brain injury. Women are at a higher risk of developing Alzheimer's disease than men, even when controlling for differences in lifespan. Women are also more likely to report high levels of stress than men. Sex differences in response to stress may play a role in the increased risk of Alzheimer's disease in women. In this study, we use in vivo microdialysis to measure levels of Abeta in response to acute stress in male and female mice. We show that Abeta levels are altered differently between female and male mice (APP/PS1 and wild-type) in response to stress, with females showing significantly increased levels of Abeta while most males do not show a significant change. This response is mediated through beta-arrestin involvement in Corticotrophin Releasing Factor receptor signalling pathway differences in male and female mice as male mice lacking beta-arrestin show increase in Abeta in response to stress similar to females. |
