| First Author | Morioka R | Year | 2001 |
| Journal | Neurosci Lett | Volume | 313 |
| Issue | 1-2 | Pages | 99-101 |
| PubMed ID | 11684349 | Mgi Jnum | J:107940 |
| Mgi Id | MGI:3622575 | Doi | 10.1016/s0304-3940(01)02224-8 |
| Citation | Morioka R, et al. (2001) Expression of vesl-1S/homer-1a, a gene associated with long-term potentiation, in the brain of the epileptic EI mouse. Neurosci Lett 313(1-2):99-101 |
| abstractText | The El mouse is an animal model for hereditary epilepsy. It undergoes a convulsive seizure lasting 10-30 s after vestibular stimulation, such as 'tossing-up'. To better characterize the effects of seizure activity in the El mouse, we examined the expression profile of vesl-1S/homer-1a mRNA in the brain. It has been shown that this mRNA is expressed after long-term potentiation or seizures induced by electrical or pharmacological stimulations. The basal level of vesl-1S mRNA was very low even in seizure-susceptible El mice. The El mouse hippocampus, but not that of ddY mice, showed a remarkable increase in vesl-1S mRNA expression in the dentate granule cell layer after seizure induced by 'tossing-up'. The mRNA remained for about 3 h after the seizure and disappeared after 8 h. |
