| First Author | Hu D | Year | 2004 |
| Journal | Nat Immunol | Volume | 5 |
| Issue | 5 | Pages | 516-23 |
| PubMed ID | 15098030 | Mgi Jnum | J:89808 |
| Mgi Id | MGI:3041664 | Doi | 10.1038/ni1063 |
| Citation | Hu D, et al. (2004) Analysis of regulatory CD8 T cells in Qa-1-deficient mice. Nat Immunol 5(5):516-23 |
| abstractText | The mouse protein Qa-1 (HLA-E in humans) is essential for immunological protection and immune regulation. Although Qa-1 has been linked to CD8 T cell-dependent suppression, the physiological relevance of this observation is unclear. We generated mice deficient in Qa-1 to develop an understanding of this process. Qa-1-deficient mice develop exaggerated secondary CD4 responses to foreign and self peptides. Enhanced responses to proteolipid protein self peptide were associated with resistance of Qa-1-deficient CD4 T cells to Qa-1-restricted CD8 T suppressor activity and increased susceptibility to experimental autoimmune encephalomyelitis. These findings delineate a Qa-1-dependent T cell-T cell inhibitory interaction that prevents the pathogenic expansion of autoreactive CD4 T cell populations and consequent autoimmune disease. |
