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Allele : Prf1<tm1Tsc> perforin 1 (pore forming protein); targeted mutation 1, Jurg Tschopp

Primary Identifier	MGI:2158418	Allele Type	Targeted
Attribute String	Null/knockout	Gene	Prf1
Transmission	Germline	Strain of Origin	129S2/SvPas
Is Recombinase	false	Is Wild Type	false

molecularNote

A neomycin selection cassette was inserted into exon 3. RT-PCR and Northern blot analysis on splenoctye RNA derived from homozygous mice demonstrated that no transcript was produced from this allele.

mutations:
Insertion

cellLines:
Not Specified

synonyms:
Prf1<->,
Kagi,
Kagi,
Prf1<->

earliestPublication:
Lowin B, et al. (1994) A null mutation in the perforin gene impairs cytolytic T lymphocyte- and natural killer cell-mediated cytotoxicity. Proc Natl Acad Sci U S A 91(24):11571-5

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

1 Carried By

0 Driven By

14 Publication categories

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