| First Author | Polakos NK | Year | 2006 |
| Journal | Am J Pathol | Volume | 168 |
| Issue | 4 | Pages | 1169-78; quiz 1404-5 |
| PubMed ID | 16565492 | Mgi Jnum | J:107338 |
| Mgi Id | MGI:3620871 | Doi | 10.2353/ajpath.2006.050875 |
| Citation | Polakos NK, et al. (2006) Kupffer Cell-Dependent Hepatitis Occurs during Influenza Infection. Am J Pathol 168(4):1169-78; quiz 1404-5 |
| abstractText | Respiratory infections, including influenza in humans, are often accompanied by a hepatitis that is usually mild and self-limiting. The mechanism of this kind of liver damage is not well understood. In the present study, we show that influenza-associated hepatitis occurs due to the formation of inflammatory foci that include apoptotic hepatocytes, antigen-specific CD8(+) T cells, and Kupffer cells. Serum aminotransaminase levels were elevated, and both the histological and serum enzyme markers of hepatitis were increased in secondary influenza infection, consistent with a primary role for antigen-specific T cells in the pathogenesis. No virus could be detected in the liver, making this a pure example of 'collateral damage' of the liver. Notably, removal of the Kupffer cells prevented the hepatitis. Such hepatic collateral damage may be a general consequence of expanding CD8(+) T-cell populations during many extrahepatic viral infections, yielding important implications for liver pathobiology. |
