| First Author | Trivedi S | Year | 2010 |
| Journal | Clin Immunol | Volume | 137 |
| Issue | 2 | Pages | 281-7 |
| PubMed ID | 20797908 | Mgi Jnum | J:168439 |
| Mgi Id | MGI:4888201 | Doi | 10.1016/j.clim.2010.07.013 |
| Citation | Trivedi S, et al. (2010) T cell vaccination therapy in an induced model of anti-RNP autoimmune glomerulonephritis. Clin Immunol 137(2):281-7 |
| abstractText | To establish the relevance of targeting disease-associated T cells in anti-RNP-associated glomerulonephritis, mice developing nephritis following immunization with U1-70-kd small nuclear ribonucleoprotein (snRNP) were treated with a single dose of irradiated antigen-selected T cell vaccine. T cell receptor usage in nephritic kidneys revealed oligoclonal use of T Cell Receptor V Beta (TRBV) genes as previously found in spleens and lungs of immunized mice with pulmonary disease. The CDR3 regions from T cell isolates showed sequence homology to those in humans with anti-RNP autoimmunity. Following T cell vaccination, urinalysis returned to normal in 5/7 treated mice (71% response rate) whereas all mock-treated mice continued to have an active urinary sediment (Fisher's Exact p=0.02). An oligoclonal population of T cells homologous to those identified in humans with anti-RNP autoimmunity is implicated in disease pathogenesis, and T cell vaccination is associated with a high rate of clinical improvement in established nephritis. |
