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Publication : Noncoding dsRNA induces retinoic acid synthesis to stimulate hair follicle regeneration via TLR3.

First Author  Kim D Year  2019
Journal  Nat Commun Volume  10
Issue  1 Pages  2811
PubMed ID  31243280 Mgi Jnum  J:278388
Mgi Id  MGI:6323722 Doi  10.1038/s41467-019-10811-y
Citation  Kim D, et al. (2019) Noncoding dsRNA induces retinoic acid synthesis to stimulate hair follicle regeneration via TLR3. Nat Commun 10(1):2811
abstractText  How developmental programs reactivate in regeneration is a fundamental question in biology. We addressed this question through the study of Wound Induced Hair follicle Neogenesis (WIHN), an adult organogenesis model where stem cells regenerate de novo hair follicles following deep wounding. The exact mechanism is uncertain. Here we show that self-noncoding dsRNA activates the anti-viral receptor toll like receptor 3 (TLR3) to induce intrinsic retinoic acid (RA) synthesis in a pattern that predicts new hair follicle formation after wounding in mice. Additionally, in humans, rejuvenation lasers induce gene expression signatures for dsRNA and RA, with measurable increases in intrinsic RA synthesis. These results demonstrate a potent stimulus for RA synthesis by non-coding dsRNA, relevant to their broad functions in development and immunity.
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