| First Author | Hamilton SE | Year | 2001 |
| Journal | Life Sci | Volume | 68 |
| Issue | 22-23 | Pages | 2489-93 |
| PubMed ID | 11392617 | Mgi Jnum | J:116511 |
| Mgi Id | MGI:3694396 | Doi | 10.1016/s0024-3205(01)01043-8 |
| Citation | Hamilton SE, et al. (2001) Alteration of cardiovascular and neuronal function in M1 knockout mice. Life Sci 68(22-23):2489-93 |
| abstractText | We used gene targeting to generate mice lacking the M1 muscarinic acetylcholine receptor. These mice exhibit a decreased susceptibility to pilocarpine-induced seizures, loss of regulation of M-current potassium channel activity and of a specific calcium channel pathway in sympathetic neurons, a loss of the positive chronotropic and inotropic responses to the novel muscarinic agonist McN-A-343, and impaired learning in a hippocampal-dependent test of spatial memory. |
