| First Author | Wilbrecht L | Year | 2010 |
| Journal | J Neurosci | Volume | 30 |
| Issue | 14 | Pages | 4927-32 |
| PubMed ID | 20371813 | Mgi Jnum | J:165065 |
| Mgi Id | MGI:4836134 | Doi | 10.1523/JNEUROSCI.6403-09.2010 |
| Citation | Wilbrecht L, et al. (2010) Structural plasticity underlies experience-dependent functional plasticity of cortical circuits. J Neurosci 30(14):4927-32 |
| abstractText | The stabilization of new spines in the barrel cortex is enhanced after whisker trimming, but its relationship to experience-dependent plasticity is unclear. Here we show that in wild-type mice, whisker potentiation and spine stabilization are most pronounced for layer 5 neurons at the border between spared and deprived barrel columns. In homozygote alphaCaMKII-T286A mice, which lack experience-dependent potentiation of responses to spared whiskers, there is no increase in new spine stabilization at the border between barrel columns after whisker trimming. Our data provide a causal link between new spine synapses and plasticity of adult cortical circuits and suggest that alphaCaMKII autophosphorylation plays a role in the stabilization but not formation of new spines. |
